L-Alanine from non-animal source, meets EP, USP testing specifications, suitable for cell culture, ≥98.5% ยี่ห้อ Sigma

PROPERTIES

biological source

non-animal source

Quality Level

200

Agency

meets EP testing specifications

meets USP testing specifications

product line

BioXtra

Assay

98.5-101.0%

form

powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

solubility

H2O: 100 mg/mL

application(s)

peptide synthesis

pharmaceutical (small molecule)

SMILES string

C[C@H](N)C(O)=O

InChI

1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1

InChI key

QNAYBMKLOCPYGJ-REOHCLBHSA-N

Gene Information

human ... CA1(759) , CA2(760)

DESCRIPTION

Application

L-Alanine has been used for tissue culture technique as a media component. It has been used as a media component for the growth of adult mouse keratinocytes.[1][2]

Biochem/physiol Actions

L-Alanine is a nonessential amino acid, which is highly concentrated in muscle.[3] It is a key player in the Glucose-Alanine cycle, which enables the removal of pyruvate and glutamate from muscle to the liver.[4][5] Once in the liver, glucose is regenerated from pyruvate and returned to the muscle while glutamate ultimately participates in the urea cycle to form urea. The Glucose-Alanine cycle aides to conserve ATP in muscle for muscle contraction, while the energy burden of gluconeogenesis is imposed upon the liver.[5][3] Alanine inhibits pyruvate kinase to regulate gluconeogenesis and glycolysis in order to maintain glucose homeostasis during starvation. Alanine prevents hepatic autophagy. Alanine formation is a result of transamination of glutamate and pyruvate.[4][3]

SAFETY INFORMATION

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable