Farnesyl pyrophosphate ammonium salt methanol:ammonia solution, ≥95% (TLC) ยี่ห้อ Sigma

PROPERTIES

Quality Level

100

Assay

≥95% (TLC)

form

methanol:ammonia solution

packaging

vial of 200 μg

storage temp.

−20°C

SMILES string

C\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O

InChI

1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+

InChI key

VWFJDQUYCIWHTN-YFVJMOTDSA-N

Gene Information

rat ... Fnta(25318)

DESCRIPTION

General description

Farnesyl pyrophosphate is a 15-carbon isoprenoid synthesized from geranyl pyrophosphate (GPP) by the action of enzyme farnesyl pyrophosphate synthase (FPPS).[1]

Application

Farnesyl pyrophosphate ammonium salt has been used:

as a prenylation agonist in human osteogenic sarcoma cells in collagen-based cell invasion assays [2]

in the prenylation of the hepatocyte growth factor (HGF) in human umbilical vein endothelial cells (HUVECs)[3]

as a substrate in prenyltransferases assay in diatom Haslea ostrearia[4]

Biochem/physiol Actions

Farnesyl pyrophosphate (FPP) is the precursor for the biosynthesis of cholesterol, ubiquinone and dolicol. It is part of the intracellular mevalonate pathway.[1] FPP is essential for cell survival[5] and is used for prenylation of several low molecular mass G proteins, including Ras.[6] Inhibition of prenylation results in loss of oncogenic potential of Ras proteins.[7] Inhibition of prenylation may serve as therapeutic potential for management of synaptic plasticity and Alzheimer′s disease.[6]

Physical form

Solution in methanol: 10mM aqueous NH4OH (7:3)

Actual concentration given on label