Caspase Inhibitor Z-VAD-FMK

A Cell-Permeant Pan Caspase Inhibitor of Apoptosis

• Irreversibly binds to catalytic site of caspase proteases
• Provided in DMSO for convenient addition to cell culture or extracts

Z-VAD-FMK (carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]- fluoromethylketone) is a cell-permeant pan caspase inhibitor that irreversibly binds to the catalytic site of caspase proteases and can inhibit induction of apoptosis. For inhibition of apoptosis, Z-VAD-FMK should be added at the same time that apoptosis is induced. Z-VAD-FMK is provided at 20mM in DMSO for convenient addition to cell culture or extracts. The peptide is O-methylated in the P1 position on aspartic acid, providing enhanced stability and increased cell permeability. The suggested concentration for use in the anti-Fas mAb-treated Jurkat cell culture model system is 20μM.

ItemPart #Size

Caspase Inhibitor, Z-VAD-FMK

G723A1 × 125μl

แหล่งที่มา : https://worldwide.promega.com/products/cell-health-assays/apoptosis-assays/caspase-inhibitor-z_vad_fmk/?catNum=G7232