3-Hydroxy-3-methylglutaryl-CoA reductase human solution ยี่ห้อ Sigma
รหัสสินค้า : H7039
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PROPERTIES
Assay
≥90% (SDS-PAGE)
Quality Level
200
form
solution
specific activity
2-8 units/mg protein
mol wt
~76 kDa (for the fusion protein)
UniProt accession no.
P04035
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... HMGCR(3156)
DESCRIPTION
Application
3-Hydroxy-3-methylglutaryl-CoA reductase human has been used:
in anti-HMGCR enzyme linked immunosorbent assay (ELISA)[1]
as an antigen to measure anti-HMGCR antibodies by blot analysis[2]
in HMG-CoA reductase activity assays[3]
as an antigen to compare in-house antigen via sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)/western blot[4]
Biochem/physiol Actions
3-Hydroxy-3-methylglutaryl-CoA reductase/HMGCR serves as a rate limiting enzyme in mevalonate pathway. It also controls the oncogenic Hippo transducers TAZ/YAP.[5] HMGCR also perform as a genetic modifier for Alzheimer′s disease (AD).[6]
Hydroxy-3-methylglutaryl-CoA reductase catalyzes the committed step in cholesterol biosynthesis.
Physical properties
Consists of the HMG CoA reductase catalytic domain fused to GST protein.
Unit Definition
One unit will convert 1.0 μmole of NADPH to NADP+ per minute at 37 °C.
Physical form
Supplied as a solution containing 250 μg protein in 50 mM Tris pH 7.5, with 5 mM DTT, 1:200 Protease Inhibitor Cocktail (Catalog Number P8340) and 50% (w/v) glycerol.
SAFETY INFORMATION
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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