Cathepsin K Inhibitor Screening Kit ยี่ห้อ Sigma
รหัสสินค้า : MAK201
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PROPERTIES
detection method
fluorometric
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CTSK(1513)
mouse ... CTSK(13038)
rat ... CTSK(29175)
DESCRIPTION
General description
Cathepsin K (CTSK; EC 3.4.22.38) is a lysosomal cysteine proteinase expressed predominantly in the osteoclasts. It exhibits potent collagenase activity and is involved in bone remodeling and resorption. Mutations in CTSK gene result in pycnodysostosis characterized by osteosclerosis and short stature.
Suitability
Suitable for the screening of inhibitors of Cathepsin K.
Principle
The Cathepsin K Inhibitor Screening Kit is a simple assay for screening potential inhibitors of CTSK. CTSK activity is measured by cleaving a synthetic 7-amino-4-trifluoromethylcoumarin (AFC)-based substrate to yield AFC, a fluorescent product (λex = 400/ λem = 505 nm), proportional to the enzymatic activity present.
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