DPP4 Inhibitor Screening Kit ยี่ห้อ Sigma
รหัสสินค้า : MAK203
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PROPERTIES
detection method
fluorometric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... DPP4(1803)
mouse ... DPP4(13482)
rat ... DPP4(25253)
DESCRIPTION
General description
Dipeptidyl-peptidase 4 (DPP4; CD26; adenosine deaminase complexing protein-2) is a membrane glycoprotein with serine exopeptidase activity that cleaves X-proline dipeptides from the N-terminus of polypeptides. Inhibitors of DPP4 inhibit the degradation of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 by DPP4 and have emerged as oral anti-diabetic agents.
Features and Benefits
Compatible with high-throughput handling systems.
Suitability
Suitable for the screening of inhibitors of DPP4.
Principle
The DPP4 Inhibitor Screening Kit is a simple assay suitable for high-throughput screening of potential DPP4 inhibitors. DPP4 activity is measured by cleaving the substrate to yield a fluorescent product (λex = 360/λem = 460 nm), proportional to the enzymatic activity present. The effectiveness of the test inhibitors may be compared with the DPP4 inhibitor (sitagliptin) provided as a control.
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