Monoamine Oxidase A (MAO-A) Inhibitor Screening Kit (Fluorometric) ยี่ห้อ Sigma

PROPERTIES

detection method

fluorometric

storage temp.

−20°C

DESCRIPTION

General description

Monoamine oxidases (MAO, EC 1.4.3.4) are a family of enzymes that can oxidize a wide variety of endogenous primary amines. Two isoforms, MAO-A and MAO-B, have been identified based on their substrate, inhibitor specificity and tissue localization. MAO-B can oxidize primary amines, but its list of specific substrates (i.e. benzylamine, phenylethylamine) is more limited compared to MAO-A.

Features and Benefits

Compatible with high-throughput handling systems.

Suitability

Suitable for screening/studying/characterizing MAO-A inhibitors.

Principle

This MAO-A Inhibitor Screening Kit offers a rapid, simple, sensitive, and reliable test suitable for high-throughput screening of MAO-A inhibitors. The assay is based on the fluorometric detection of hydrogen peroxide (H2O2), one of the by-products generated during the oxidative deamination of the MAO substrate (tyramine).