Sodium palmitate ≥98.5% ยี่ห้อ Sigma

PROPERTIES

biological source

plant (palm)

Quality Level

200

Assay

≥98.5%

form

powder

mp

283-290 °C (lit.)

functional group

ester

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Na+].CCCCCCCCCCCCCCCC([O-])=O

InChI

1S/C16H32O2.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18;/h2-15H2,1H3,(H,17,18);/q;+1/p-1

InChI key

GGXKEBACDBNFAF-UHFFFAOYSA-M

DESCRIPTION

Application

Sodium palmitate (PA) has been used:

to induce inflammation and thrombosis pathway in murine macrophage cell line RAW 264.7 cell line by activating reactive oxygen species (ROS) production, Janus-kinase (JNK) signalling and release of histone H3 by western blotting and cell viability by MTT assay[1]

to induce lipogenesis in AML12 cells and primary hepatocytes to analyse the effect of irisin on PA induced lipogenesis and related signal pathways by western blot analysis and quantitative PCR analysis[2]

as a component in free fatty acid mixture to induce cellular steatosis in HepG2 cell lines and determination of lipid accumulation by Oil-Red-O staining[3]

Biochem/physiol Actions

Sodium palmitate is the sodium salt of palmitic acid, a component in hard soaps.[4] Palmitic acid is a common saturated fatty acid and produced during fatty acid synthesis. Sodium palmitate enhances lipogenesis,[2] cellular steatosis in various cell lines.[3] Palmitate induces cell death in human epidermal growth factor receptor 2 (HER2)/neu-positive cells and breast cancer cell lines like MCF-7 due to enhanced fatty acid accumulation.[5] Sodium palmitate induces lipoapoptosis in L02 and HepG2 liver cells by inducing glycogen synthase kinase-3β (GSK3β) expression.[6]

SAFETY INFORMATION

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable