Anti-PDHA1 antibody produced in mouse ยี่ห้อ Sigma

รหัสสินค้า : SAB1406239

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PROPERTIES

biological source

mouse


Quality Level

100


conjugate

unconjugated


antibody form

purified immunoglobulin


antibody product type

primary antibodies


clone

polyclonal


form

buffered aqueous solution


mol wt

antigen ~43.01 kDa


species reactivity

human

 

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

western blot: 1 μg/mL


NCBI accession no.

BC002406

 

UniProt accession no.

P08559


shipped in

dry ice


storage temp.

−20°C


Gene Information

human ... PDHA1(5160)

 

DESCRIPTION

General description

The pyruvate dehydrogenase complex is a nuclear-encoded mitochondrial matrix multienzyme complex that provides the primary link between glycolysis and the tricarboxylic acid (TCA)

cycle by catalyzing the irreversible conversion of pyruvate into acetyl-CoA. The PDH complex is composed of multiple copies of 3 enzymes: E1 (PDHA1); dihydrolipoyl transacetylase

(DLAT; MIM 608770) (E2; EC 2.3.1.12); and dihydrolipoyl dehydrogenase (DLD; MIM 238331) (E3; EC 1.8.1.4). The E1 enzyme is a heterotetramer of 2 alpha and 2 beta subunits.

The E1-alpha subunit contains the E1 active site and plays a key role in the function of the PDH complex (Brown et al., 1994 [PubMed 7853374]).[supplied by OMIM

Immunogen

PDHA1 (AAH02406, 1 a.a. ~ 390 a.a) full-length human protein.


Sequence

MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRAHGFTFTRGLS

VREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAASTDYYKRGDFIPGLRVDGMD

ILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVSYRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPPLEELGYHIYSSDPPFEVRGANQWIKFKSVS

Physical form

Solution in phosphate buffered saline, pH 7.4

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


SAFETY INFORMATION

Storage Class Code

13 - Non Combustible Solids


WGK

WGK 1


Flash Point(F)

Not applicable

 

Flash Point(C)

Not applicable

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