Zoledronic acid monohydrate ≥98% (HPLC) ยี่ห้อ Sigma
รหัสสินค้า : SML0223
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PROPERTIES
Quality Level
100
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
protect from light
color
white to beige
solubility
H2O: ≥2 mg/mL
storage temp.
2-8°C
SMILES string
O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
InChI
1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
InChI key
FUXFIVRTGHOMSO-UHFFFAOYSA-N
DESCRIPTION
Application
Zoledronic acid monohydrate has been used:
as an inhibitor for cell proliferation in glioblastoma, breast cancer tumor[1] and prostate cancer cell line LAPC4[2]
as a conjugate with D,L-lactide 75: glycolide 25 (PLGA) to analyze its bone formation functionality in distal femur[3]
as an inhibitor for farnesyl diphosphate synthase enzyme in glioblastoma cells[4]
Biochem/physiol Actions
Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones.
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