Promega nucleic acid extraction chemistries cover a full range of sample throughput needs--from single-prep manual solutions through benchtop automation to plate-based systems compatible with robotic liquid handlers.

Here, you’ll find a range of nucleic acid extraction products that generate high yields of high-quality genomic DNA, plasmid DNA, RNA or total nucleic acid from many sample types. We also provide products for clean up and concentration of DNA or RNA from dilute solutions, gel slices or PCR. 

From endpoint PCR to quantitative real-time PCR and RT-PCR, we offer a complete portfolio of high-quality products to meet your amplification needs. Endpoint and real-time PCR products feature GoTaq® (Taq) DNA polymerase in convenient master mixes, kits and flexible enzyme formulations for basic PCR, hot-start PCR, long-range PCR, qPCR and RT-qPCR.

We offer a range of biochemicals and supplies for routine use in the molecular biology lab. This is the place to find buffers and other basic biochemicals and reagents commonly used in molecular biology experiments. 

Promega provides complete solutions for analysis of forensic DNA samples by capillary electrophoresis (CE). These include reagents and kits for all steps in CE analysis workflows.

Promega offers solutions for forensic DNA analysis using a massively parallel sequencing (MPS) workflow. We provide preprocessing reagents and automation-friendly DNA isolation systems for processing casework samples in a streamlined workflow. The PowerQuant® System provides accurate, human-specific DNA quantitation. PowerSeq® products allow target amplification of short tandem repeats (STRs) for MPS analysis of both Y-chromosome and autosomal DNA, as well as for preparation of Illumina® sequencing libraries for mitochondrial control region DNA.

Promega provides a wide range of products to help streamline and support clinical laboratory workflows, including GPR, GPLE and cGMP level quality instruments and reagents for nucleic acid purification, PCR, STR analysis, genetic analysis and mutation detection.

STRs (short tandem repeats) are repetitive sequence elements 3–7 base pairs in length scattered throughout the human genome. By amplifying and analyzing these polymorphic loci, and then comparing the resulting STR profile to that of a reference sample, the origin of biological samples such as cells or tissues can be identified and verified. The more loci that are amplified, the higher the statistical power of discrimination.

A recombinant protein is a protein encoded by a gene—recombinant DNA—that has been cloned in a system that supports expression of the gene and translation of messenger RNA. Modification of the gene by recombinant DNA technology can lead to the expression of a mutant protein. Promega provides products for both the expression of recombinant proteins in cell-based E. coli systems and a variety of cell-free systems, such as rabbit reticulocyte lysate (RRL) or wheat germ extract (WGE).

Luciferase assays can be used to investigate a variety of cellular processes using bioluminescent light output as a sensitive measure of biological activity. We offer a full range of luciferase assay products and tools for your research.

Promega cell signaling products use the power and convenience of bioluminescence to detect and quantify the activity of various enzymes and proteins involved in signal transduction cascades. 

This collection of plasmid vectors includes basic cloning and subcloning vectors, bioluminescent reporter vectors for monitoring signaling events and miRNA activity, and protein expression vectors for use in cell-free and cell-based protein expression systems.

We offer a broad range of tools for detecting and quantifying proteins, from traditional immunological detection reagents to novel methods that monitor protein abundance in live cells.

We offer a portfolio of easy-to-use assays that can be used together to provide a comprehensive assessment of cell health in multiple model systems and sample types, including monolayer cell cultures, 3D microtissues, organoids, primary cells, and stem cells.

Protein purification is fundamental to the study of protein function and involves a series of processes to express, enrich and purify a protein of interest from a complex mixture such as cell lysate. The fastest and most powerful method for this purpose is affinity purification. We offer a range of protein purification kits and reagents for purification of recombinant proteins using affinity tags such as HaloTag, GST- or His-tag. We also offer Magne® Protein G/A Beads, which provide an easy-to-use and rapid method for purification of polyclonal and monoclonal antibodies from serum, ascites fluid and cell culture medium.

Promega offers kits and reagents for the analysis of DNA methylation, histone modification and RNA transcription to support your epigenetic research.

Promega offers an extensive toolbox of reporter bioassays to characterize and develop novel monoclonal antibody (mAb) and cell-based therapeutics.